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KMID : 0360419820180020051
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Korean Journal of Pharmacology
1982 Volume.18 No. 2 p.51 ~ p.58
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Influences of Phenytoin and Phenobarbital on the Changes of Brain Norepinephrine Content and Plasma Corticosterone Level in Mice
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Abstract
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In this paper, the influence of phenytoin and phenobarbical on the changes of brain norepinephrine (NE) content, plasma corticosterone and blood sugar level in mice were studied. The results obtained were summarized as follows:
1) Phenytoin(50 mg/kg) increased the brain NE content but phenobarbital(50 mg/kg) did not affect. The increase of the brain NE content induced by phenytoin was potentiated by phenobarbital pretreatment.
2) Phenytoin (25 mg/kg, 50 mg/kg) markedly increased the level of plasma corticosterone but phenobarbital did not affect. The increase of the plasma corticosterone induced by phenytoin was inhibited by phenobarbital pretreatment.
3) Phenytoin (50 mg/kg) markedly increased the blood sugar level but phenobarbital did not affect. The increase of the blood sugar induced by phenytoin was not affected by phenobarbital pretreatment.
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